Format

Send to

Choose Destination
Gene Ther. 2013 Mar;20(3):348-52. doi: 10.1038/gt.2012.27. Epub 2012 Mar 15.

Axonal transport of adeno-associated viral vectors is serotype-dependent.

Author information

1
Department of Neurosurgery, University of California San Francisco, San Francisco, CA 94103-0555, USA.

Abstract

We have previously shown that adeno-associated virus type 2 (AAV2) undergoes anterograde axonal transport in rat and non-human primate brain. We screened other AAV serotypes for axonal transport and found that AAV6 is transported almost exclusively in a retrograde direction and, in the same way as AAV2, it is also neuron-specific in rat brain. Our findings show that axonal transport of AAV is serotype dependent and this has implications for gene therapy of neurological diseases such as Huntington's disease.

PMID:
22418061
PMCID:
PMC3381869
DOI:
10.1038/gt.2012.27
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center