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J Am Chem Soc. 2012 Mar 28;134(12):5544-7. doi: 10.1021/ja301278p. Epub 2012 Mar 19.

Dynamics of a supramolecular capsule assembly with pyrene.

Author information

1
Department of Chemistry, University of Victoria, Victoria, BC, Canada.

Abstract

Water-soluble octaacid cavitands (OAs) form dimeric capsules suitable for guest incorporation. Our studies reveal that the mechanism of pyrene (Py) binding involves the rapid (<1 ms) formation of the Py·OA complex followed by slower binding with the second OA. The dissociation of the capsular OA·Py·OA complex occurs with a lifetime of 2.7 s, which is 5 orders of magnitude slower than the microsecond opening/closing ("breathing") previously observed to provide access of small molecules to the encapsulated guest. These different dynamics of the capsules have a potential impact on how the chemistry of included guests could be altered.

PMID:
22417319
PMCID:
PMC3315598
DOI:
10.1021/ja301278p
[Indexed for MEDLINE]
Free PMC Article

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