Efficacy of maduramicin ammonium against coccidiosis in turkeys under laboratory and floor-pen conditions

Avian Dis. 1990 Jul-Sep;34(3):634-8.

Abstract

Experimental infections with field isolates of Eimeria meleagrimitis, E. adenoeides, E. gallopavonis, and E. dispersa in turkey poults were used to test the efficacy of maduramicin ammonium at 2.5-10 ppm in laboratory experiments. Infection with single or mixed species of coccidia reduced the weight gain of unmedicated infected controls and caused 18.1-65% mortality in two experiments. Maduramicin ammonium given at 5-7 ppm prevented mortality, significantly reduced droppings scores and oocyst passage, and improved weight gain to near that of the unmedicated uninfected controls. Maduramicin ammonium was tested at 4-7 ppm in a floor-pen trial lasting 10 weeks. Mortality from coccidiosis averaged 11.9% in unmedicated controls, compared with 0.6% with 4 ppm of maduramicin or no mortality with 5-7 ppm. Average weight gain and feed conversion at 10 weeks were significantly improved over unmedicated infected controls when maduramicin ammonium was given at 5-7 ppm. These results suggest that maduramicin ammonium is highly efficacious against field isolates of Eimeria in turkeys, especially within the range of 5-7 ppm in the feed.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Coccidiosis / drug therapy
  • Coccidiosis / veterinary*
  • Coccidiostats / therapeutic use
  • Female
  • Lactones / therapeutic use
  • Male
  • Poultry Diseases / drug therapy*
  • Random Allocation
  • Turkeys / parasitology*

Substances

  • Anti-Bacterial Agents
  • Coccidiostats
  • Lactones
  • maduramicin