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Arch Neurol. 1990 Nov;47(11):1245-54.

Background review and current concepts of reperfusion injury.

Author information

1
Neurology Department, National Naval Medical Center, Bethesda, MD 20814-5011.

Erratum in

  • Arch Neurol 1991 Aug;48(8):811.

Abstract

We define the concept of reperfusion injury, and we present a background chronology of experimental work supporting and questioning this concept. We identify several new influences, such as current clinical interest in thrombolytic therapy for acute ischemia of heart and brain and the growing recognition of endothelium as a regulator of homeostasis. We propose that these influences will encourage a reexamination of reperfusion injury as a factor in the ultimate outcome of tissue exposed to reversible ischemia. We briefly discuss the major mechanisms presently implicated in reperfusion injury--loss of calcium homeostasis, free radical generation, leukocyte-mediated injury, and acute hypercholesterolemia.

[Indexed for MEDLINE]

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