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J Infect Dis. 2012 Apr 15;205(8):1220-4. doi: 10.1093/infdis/jis178. Epub 2012 Mar 13.

Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008-2010.

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1
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia.

Abstract

Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.

PMID:
22416243
DOI:
10.1093/infdis/jis178
[Indexed for MEDLINE]

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