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Sci China Life Sci. 2012 Feb;55(2):109-18. doi: 10.1007/s11427-012-4279-x. Epub 2012 Mar 15.

Viral suppression of RNA silencing.

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1
State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China.

Abstract

Gene silencing (RNA silencing) plays a fundamental role in antiviral defense in plants, fungi and invertebrates. Viruses encode proteins that suppress gene silencing to counter host defense. Viral suppressors of RNA silencing (VSRs) have been identified from almost all plant virus genera and some viruses of insects and mammals. Recent studies have revealed that VSRs counter host defense and interfere with host gene regulation by interacting with RNA or important components of the RNA silencing pathway. Here, we review the current understanding of the complex mechanisms of VSRs that have been revealed by recent studies.

PMID:
22415681
DOI:
10.1007/s11427-012-4279-x
[Indexed for MEDLINE]
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