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Transcription. 2012 Mar-Apr;3(2):78-86. doi: 10.4161/trns.19349. Epub 2012 Mar 1.

Transcription control by long non-coding RNAs.

Author information

1
Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.

Abstract

Non-coding RNAs have been found to regulate many cellular processes and thus expand the functional genetic repertoire contained within the genome. With the recent advent of genomic tools, it is now evident that these RNA molecules play central regulatory roles in many transcriptional programs. Here we discuss how they are targeted to promoters in several cases and how they operate at specific points in the transcription cycle to precisely control gene expression.

PMID:
22414755
PMCID:
PMC3337829
DOI:
10.4161/trns.19349
[Indexed for MEDLINE]
Free PMC Article

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