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J Org Chem. 2012 Apr 6;77(7):3609-14. doi: 10.1021/jo300039q. Epub 2012 Mar 20.

Synthesizing the tetracyclic core of nanolobatolide.

Author information

1
Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.

Abstract

A concise synthetic pathway that enables the stereoselective construction of the tetracyclic core of nanolobatolide has been developed by applying a tandem ring-closing metathesis (RCM) reaction of dienynes, a Eu(fod)(3)-catalyzed intermolecular Diels-Alder reaction, and a biomimetic epoxide opening reaction as key steps.

PMID:
22414060
DOI:
10.1021/jo300039q
[Indexed for MEDLINE]

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