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Nat Rev Genet. 2012 Mar 13;13(4):227-32. doi: 10.1038/nrg3185.

Insights into the regulation of protein abundance from proteomic and transcriptomic analyses.

Author information

1
Center for Genomics and Systems Biology, New York University, New York 10003, USA. cvogel@nyu.edu

Abstract

Recent advances in next-generation DNA sequencing and proteomics provide an unprecedented ability to survey mRNA and protein abundances. Such proteome-wide surveys are illuminating the extent to which different aspects of gene expression help to regulate cellular protein abundances. Current data demonstrate a substantial role for regulatory processes occurring after mRNA is made - that is, post-transcriptional, translational and protein degradation regulation - in controlling steady-state protein abundances. Intriguing observations are also emerging in relation to cells following perturbation, single-cell studies and the apparent evolutionary conservation of protein and mRNA abundances. Here, we summarize current understanding of the major factors regulating protein expression.

PMID:
22411467
PMCID:
PMC3654667
DOI:
10.1038/nrg3185
[Indexed for MEDLINE]
Free PMC Article

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