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Adv Exp Med Biol. 2012;729:83-94. doi: 10.1007/978-1-4614-1222-9_6.

Caveolin-1 and breast cancer: a new clinical perspective.

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1
Department of Stem Cell Biology and Regenerative Medicine, Thomas Jefferson University, Philadelphia, PA, USA. isabelle.mercier@jefferson.edu

Abstract

The current chapter focuses on the role of Caveolin-1 (Cav-1) in cellular growth with an emphasis on its implication in breast cancer initiation, progression, clinical prognosis and as a potential therapeutic target. The role of Cav-1 as a tumor suppressor in breast cancer has emerged in the past few years, with dual functions on both cancer epithelium as well as the cancer stroma. Its multiple functions as a regulator of estrogen signaling and kinase activity and its newly found role as an important factor controlling the dynamic relationship between cancer epithelia and stroma position Cav-1 as a new therapeutic target for the treatment of breast cancer.

PMID:
22411315
DOI:
10.1007/978-1-4614-1222-9_6
[Indexed for MEDLINE]
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