Format

Send to

Choose Destination
See comment in PubMed Commons below
Adv Exp Med Biol. 2012;724:317-31. doi: 10.1007/978-1-4614-0653-2_24.

Premature aging syndrome.

Author information

1
Department of Human and Environmental Sciences, Section of Medical Genetics, University of Pisa, Italy. f.coppede@geog.unipi.it

Abstract

Hutchinson-Gilford progeria syndrome and Werner syndrome are two of the best characterized human progeroid diseases with clinical features mimicking physiological aging at an early age. Both disorders have been the focus of intense research in recent years since they might provide insights into the pathology of normal human aging. The chapter contains a detailed description of the clinical features of both disorders and then it focuses on the genetics, the resulting biochemical alterations at the protein level and the most recent findings and hypotheses concerning the molecular basis of the premature aging phenotypes. A description of available diagnostic and therapeutic approaches is included.

PMID:
22411253
DOI:
10.1007/978-1-4614-0653-2_24
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Springer
    Loading ...
    Support Center