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Best Pract Res Clin Haematol. 2012 Mar;25(1):75-89. doi: 10.1016/j.beha.2012.01.005. Epub 2012 Feb 5.

EBV-associated lymphomas in adults.

Author information

1
Walter Reed National Military Medical Center, Bethesda, MD 20814, USA. roschewski@mail.nih.gov

Abstract

Epstein-Barr virus (EBV) is a ubiquitous γ-herpes virus that infects most people but results in life-threatening diseases in only a small subset. Persons who are unable to maintain the virus in its latent state can develop uncontrolled EBV-driven lymphoproliferative disorders and lymphomas. EBV-associated lymphomas are well characterized in patients with known defects in cellular immunity as occurs post-transplantation or HIV/AIDS but are increasingly recognized in patients without overt immunodeficiencies. Improved understanding of the biology of these lymphomas and the role EBV plays in lymphomagenesis offer the opportunity for improved therapies targeted at important signaling pathways and immunotherapy specific against EBV viral antigens.

PMID:
22409825
PMCID:
PMC3305910
DOI:
10.1016/j.beha.2012.01.005
[Indexed for MEDLINE]
Free PMC Article
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