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Anal Chem. 2012 Apr 17;84(8):3696-702. doi: 10.1021/ac300204z. Epub 2012 Apr 3.

Contactless NMR spectroscopy on a chip.

Author information

1
Department of Mechanical and Aeropspace Engineering, University of Virginia, Charlottesville, Virginia 22904, United States.

Abstract

Inductively coupled planar resonators offer convenient integration of high-resolution NMR spectroscopy with microfluidic lab-on-a-chip devices. Planar spiral resonators are fabricated lithographically either by gold electroplating or by etching Cu laminated with polyimide. Their performance is characterized by NMR imaging as well as spectroscopy. A single-scan limit of detection LOD(t) = 0.95 nmol s(1/2) was obtained from sample volumes around 1 μL. The sensitivity of this approach is similar to that obtained by microstripline and microslot probes.

PMID:
22409303
DOI:
10.1021/ac300204z
[Indexed for MEDLINE]

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