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Int J Mol Sci. 2012;13(2):2368-86. doi: 10.3390/ijms13022368. Epub 2012 Feb 22.

Impaired iron status in aging research.

Author information

1
Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA.

Abstract

Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.

KEYWORDS:

aging; iron accumulation; labile iron; mitochondrial dysfunction; oxidative damage

PMID:
22408459
PMCID:
PMC3292028
DOI:
10.3390/ijms13022368
[Indexed for MEDLINE]
Free PMC Article
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