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Brief Bioinform. 2013 Jan;14(1):1-12. doi: 10.1093/bib/bbs007. Epub 2012 Mar 9.

The automatic annotation of bacterial genomes.

Author information

1
The Roslin Institute, University of Edinburgh, Easter Bush, EH25 9RG, UK.

Abstract

With the development of ultra-high-throughput technologies, the cost of sequencing bacterial genomes has been vastly reduced. As more genomes are sequenced, less time can be spent manually annotating those genomes, resulting in an increased reliance on automatic annotation pipelines. However, automatic pipelines can produce inaccurate genome annotation and their results often require manual curation. Here, we discuss the automatic and manual annotation of bacterial genomes, identify common problems introduced by the current genome annotation process and suggests potential solutions.

PMID:
22408191
PMCID:
PMC3548604
DOI:
10.1093/bib/bbs007
[Indexed for MEDLINE]
Free PMC Article

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