Format

Send to

Choose Destination
Eur Spine J. 2012 Jul;21(7):1396-409. doi: 10.1007/s00586-012-2212-4. Epub 2012 Mar 10.

Morphological changes in disc herniation in the lower cervical spine: an ultrastructural study.

Author information

1
Department of Traumatology, Medical University of Innsbruck, Anichstr 35, 6020 Innsbruck, Austria. ingrid.sitte@i-med.ac.at

Abstract

INTRODUCTION:

The basis of disc degeneration is still unknown, but is believed to be a cell-mediated process. Apoptosis might play a major role in degenerative disc disease (DDD). The aim of this study was to correlate the viability of disc cells with the radiological degeneration grades (rDG) in disc herniation.

MATERIALS AND METHODS:

Forty anterior IVD's (C4-C7) from 39 patients with DDD were studied histologically and ultrastructurally to quantify healthy, "balloon", chondroptotic, apoptotic and necrotic cells. Patients were classified to their rDG, as having either prolapse (P: DGII + III) and/or osteochondrosis (O: DGIV + V). Similar studies were undertaken on eight control discs.

RESULTS:

Cell death by necrosis (mean 35%) was common but differed not significantly in both groups. All patients with a disc prolapse DGII + III revealed balloon cells (iAF: mean 32%). All appeared alive and sometimes were hypertrophic. However, significantly less balloon cells were found in the O-Group. Control samples revealed no evidence of "balloon" cells in DGII and only a minor rate in DGIII.

CONCLUSION:

According to the different rDG, quantitative changes were obvious in healthy and "balloon" cells, but not for cell death. At the moment it can only be hypothesized if "balloon" cells are part of a repair strategy and/or cause of disc herniation.

PMID:
22407261
PMCID:
PMC3389114
DOI:
10.1007/s00586-012-2212-4
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center