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Hosp Pract (1995). 2012 Feb;40(1):139-48. doi: 10.3810/hp.2012.02.954.

Clostridium difficile colitis: a review.

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1
Director, Infectious Diseases Fellowship Program, St. Joseph Mercy Hospital, Ann Arbor, MI 48106, USA. moudgalv@trinity-health.org

Abstract

Clostridium difficile has become an increasingly important nosocomial pathogen and is one of the most common causes of hospital-acquired diarrhea. The incidence of C difficile infection (CDI) is increasing worldwide. Overuse of antibiotics is felt to be a major contributing factor leading to the increased incidence of CDI. The clinical manifestations of CDI vary from a mild form of the disease to fulminant diarrhea, leading to significant patient morbidity and mortality. The increasing incidence of CDI has a major impact on increasing health care costs. This article will summarize the epidemiology, pathogenesis, clinical manifestations, laboratory diagnosis, and treatment options for CDI, as well as infection-control measures for the prevention of CDI.

PMID:
22406889
DOI:
10.3810/hp.2012.02.954
[Indexed for MEDLINE]
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