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Nat Neurosci. 2012 Mar 11;15(4):537-9. doi: 10.1038/nn.3057.

Dense representation of natural odorants in the mouse olfactory bulb.

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1
Department of Basic Neurosciences, School of Medicine, University of Geneva, Geneva, Switzerland.

Abstract

In mammals, odorant molecules are thought to activate only a few glomeruli, leading to the hypothesis that odor representation in the olfactory bulb is sparse. However, the studies supporting this model used anesthetized animals or monomolecular odorants at limited concentration ranges. Using optical imaging and two-photon microscopy, we found that natural odorants at their native concentrations could elicit dense representations in the olfactory bulb. Both anesthesia and odorant concentration were found to modulate the representation density of natural odorants.

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PMID:
22406552
PMCID:
PMC3570072
DOI:
10.1038/nn.3057
[Indexed for MEDLINE]
Free PMC Article

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