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Mol Cell. 2012 Mar 9;45(5):585-6. doi: 10.1016/j.molcel.2012.02.011.

Keeping it together in times of stress: checkpoint function at stalled replication forks.

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  • 1Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94158, USA.


In this issue of Molecular Cell, De Piccoli et al. (2012) show that, contrary to current models of DNA replication checkpoint function, replication proteins remain associated with each other and with replicating DNA when replication is stressed in checkpoint-deficient cells.

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