Format

Send to

Choose Destination
Acta Obstet Gynecol Scand. 2012 Jun;91(6):726-35. doi: 10.1111/j.1600-0412.2012.01391.x. Epub 2012 May 1.

Maternal lipids at mid-pregnancy and the risk of preterm delivery.

Author information

1
Department of Health, Leisure, and Exercise Science, Appalachian State University, Boone, NC, USA.

Abstract

OBJECTIVE:

This study examined associations between maternal lipid levels at mid-pregnancy and preterm delivery, medically indicated or spontaneous.

DESIGN:

Prospective cohort study.

SETTING:

Women were recruited from 52 clinics in five Michigan, USA communities (1998-2004).

POPULATION:

Pregnant women were enrolled at 15-27 weeks' gestation and followed to delivery (n=3019).

METHODS:

A single blood sample was obtained at study enrollment. Blood lipids, i.e. total cholesterol (TC), high-density lipoprotein (HDLc), low-density lipoprotein (LDLc) cholesterol, and triglycerides (TG), were measured on a sub-cohort (n=1309).

MAIN OUTCOME MEASURES:

There were 221 spontaneous, 100 medically indicated preterm deliveries and 988 term deliveries. Polytomous logistic regression models examined relationships among cholesterol levels (Low: <10(th) percentile, Referent: 10(th) -<70(th) percentile, High: ≥70(th) percentile), quartiles of TG (Referent: first quartile) and delivery outcome (Referent: term).

RESULTS:

Odds of medically indicated preterm delivery were increased among women with low TC (adjusted odds ratio (aOR)=2.04, 95% confidence interval (CI): 1.12, 3.72), low HDLc (aOR=1.89, 95%CI: 1.04, 3.42) or low LDLc (aOR=1.96, 95%CI: 1.09, 3.54). Odds of spontaneous preterm delivery were increased among women with high TC (aOR=1.51, 95%CI: 1.06, 2.15), high LDLc (aOR=1.42, 95%CI: 0.99, 2.04) or high TG (aOR=1.90, 95%CI: 1.21, 2.97 and aOR=1.72, 95%CI: 1.06, 2.78 for third and fourth quartiles, respectively).

CONCLUSIONS:

Extremely low TC, HDLc, and LDLc were associated with a modest increase in risk of medically indicated preterm delivery, whereas high TC, LDLc and TG modestly increased the risk of spontaneous preterm delivery. Further research is needed to uncover explanations for these associations and to identify optimal ranges for maternal lipids.

PMID:
22404756
PMCID:
PMC4563824
DOI:
10.1111/j.1600-0412.2012.01391.x
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center