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Clin Microbiol Infect. 2013 Mar;19(3):249-56. doi: 10.1111/j.1469-0691.2012.03797.x. Epub 2012 Mar 8.

Early non-invasive ventilation treatment for severe influenza pneumonia.

Collaborators (261)

Cobo P, Martins J, Carbayo C, Robles-Musso E, Cárdenas A, Fierro J, Fernández DO, Sierra R, Huertos MJ, Pozo JC, Guerrero R, Sofía R, Márquez E, Rodríguez-Carvajal M, Jiménez JR, Jareño A, Estella A, Pomares J, Ballesteros JL, Fernández Y, Lobato F, Prieto JF, Albofedo-Sánchez J, Martínez P, Castellanos MA, Sevilla G, Garnacho-Montero J, Hinojosa R, Fernández E, Loza A, León C, Arenzana A, Ocaña D, Navarrete I, Beryanaki MZ, Sánchez I, Avellanas ML, Lacueva MI, Luque P, Blesa L, González I, Servet M, Montón JM, Polanco O, Regil PD, Villanova R, Iglesias L, González CP, García-Rodríguez Á, Socias L, Ibánez P, Borges-Sa M, Socias A, Del Castillo A, Marcos RJ, Bonell JM, Amestarán I, Ruiz-Santana S, Díaz JJ, Ferrer J, Sole-Violan J, Molina J, Hernández D, Trujillo A, Regalado L, Lorente L, Martín M, Martínez S, Cáceres JJ, Suberviola B, Ugarte P, García-López F, Alonso AÁ, Pasilla A, Grande LG, Albaya A, Canabal A, Marina L, Simón A, Añón JM, Messa BL, Pueyo MJ, Ferreras Z, Macias S, Berezo JÁ, Varela JB, Ojeda A A, Terrero AÁ, Ezpeleta FT, Paez Z, García Á, Vega V, Catalán RM, Ferrer M, Torres A, Barbadillo S, Cabré L, Rovira A, Álvarez-Lerma F, Vázquez A, Nolla J, Fernández F, Cervelló JR, Mañéz R, Ballús J, Granada RM, Vallés J, Ortíz M, Guía C, Arméstar F, Páez J, Almirall J, Balanzo X, Arnau E, Laborda C, Souto J, Masclans JR, Llopart L, Sanchez A, Catalán I, de Déu SJ, Sirvent JM, Ferri C, de Arbina NL, Trueta J, Badía M, Valverdú-Vidal M, Barcenilla F, de Vilanova A, Magret M, Esteban MF, Luna J, Nava JM, de Molina JG, Josic Z, Gurri F, Rello J, Rodríguez A, Lisboa T, de Mendoza D, Parra A, Garcia E, XXIII J, Díaz RM, Mesalles E, José JN, Cristina I, Fernández-Zapata A, Recio T, Arrascaeta A, García-Ramos J, Gallego E, Bueno F, Díaz M, Cordero L, Pastor JA, Álvarez-Rocha L, Coruña A, Vila D, Lamas AD, Blanco Pérez J, Ortiz Piquer M, Merayo E, López-Ciudad VJ, Cortez J, Vilaboy E, Saborido EM, González RJ, López AM, Canabal J, Ferres E, Monzón JL, Goñi F, Del Nogal Sáez F, Navalpotro MB, Ochoa S, García-Torrejón M, Pérez-Calvo C, López D, Arnaiz L, Sánchez-Alonso S, Velayos C, del Río F, González MÁ, Martín MC, Molina JM, Montejo JC, Catalán M, Albert P, de Pablo A, Guerrero JE, Peyrat JB, Marañón G, Cerdá E, Alvarez M, Pey C, Rodríguez M, Palencia E, Caballero R, Vaquero C, Mariscal F, García-Plaza S, Carrasco N, Prieto I, Liétor A, Ramos R, Galván B, Figueira JC, Soriano M, Galdós P, Moreno BB, Cabo Fd, Hermosa C, Gordo F, Algora A, Paredes A, Cambronero JA, Gómez-Rosado S, López LM, Martínez S, Abad F, Martínez M, Butí SM, Rueda BG, García F, Messeguer M, Maraví-Poma E, Jimenez Urra I, Redin LM, Tellería A, Insansti J, González N, Marco P, Vidaur L, Perez-Trallero E, Santamaría B, Vergara JC, Amiano JR, Manzano A, Arenal CC, Olaechea PM, Blanquer J, Valero RR, Belenger A, Altaba S, Álvarez-Sánchez B, Picos A, Sánchez-Miralles Á, Bonastre J, Palamo M, Cebrian J, Cuñat J, Romero B, Zaragoza R, Paricio V, Marques A, Sánchez-Morcillo S, Tormo S, Latour J, García MÁ, Ribas A.

Author information

1
Critical Care Department, Vall d'Hebron University Hospital, Vall d'Hebron Research Institute (VHIR), Universitat Autònoma de Barcelona, Barcelona, Spain.

Abstract

The role of non-invasive ventilation (NIV) in acute respiratory failure caused by viral pneumonia remains controversial. Our objective was to evaluate the use of NIV in a cohort of (H1N1)v pneumonia. Usefulness and success of NIV were assessed in a prospective, observational registry of patients with influenza A (H1N1) virus pneumonia in 148 Spanish intensive care units (ICUs) in 2009-10. Significant variables for NIV success were included in a multivariate analysis. In all, 685 patients with confirmed influenza A (H1N1)v viral pneumonia were admitted to participating ICUs; 489 were ventilated, 177 with NIV. The NIV was successful in 72 patients (40.7%), the rest required intubation. Low Acute Physiology and Chronic Health Evaluation (APACHE) II, low Sequential Organ Failure Assessment (SOFA) and absence of renal failure were associated with NIV success. Success of NIV was independently associated with fewer than two chest X-ray quadrant opacities (OR 3.5) and no vasopressor requirement (OR 8.1). However, among patients with two or more quadrant opacities, a SOFA score ≤7 presented a higher success rate than those with SOFA score >7 (OR 10.7). Patients in whom NIV was successful required shorter ventilation time, shorter ICU stay and hospital stay than NIV failure. In patients in whom NIV failed, the delay in intubation did not increase mortality (26.5% versus 24.2%). Clinicians used NIV in 25.8% of influenza A (H1N1)v viral pneumonia admitted to ICU, and treatment was effective in 40.6% of them. NIV success was associated with shorter hospital stay and mortality similar to non-ventilated patients. NIV failure was associated with a mortality similar to those who were intubated from the start.

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