Send to

Choose Destination
See comment in PubMed Commons below
Front Mol Neurosci. 2012 Mar 1;5:24. doi: 10.3389/fnmol.2012.00024. eCollection 2012.

Epigenetic regulation of axon and dendrite growth.

Author information

Neuroscience Program, University of Miami Miller School of Medicine, Miami FL, USA.


Neuroregenerative therapies for central nervous system (CNS) injury, neurodegenerative disease, or stroke require axons of damaged neurons to grow and re-innervate their targets. However, mature mammalian CNS neurons do not regenerate their axons, limiting recovery in these diseases. Although neurons' intrinsic capacity for axon growth may depend in part on the panoply of expressed transcription factors, epigenetic factors such as the accessibility of DNA and organization of chromatin are required for downstream genes to be transcribed. Thus, a potential approach to overcoming regenerative failure focuses on the epigenetic mechanisms regulating regenerative gene expression in the CNS. Here we review molecular mechanisms regulating the epigenetic state of DNA through chromatin modifications, their implications for regulating axon and dendrite growth, and important new directions for this field of study.


axon growth; axon regeneration; central nervous system; chromatin; dendrite growth; epigenetics; transcription; transcription factors

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center