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Subcell Biochem. 2012;58:111-81. doi: 10.1007/978-94-007-3012-0_5.

PI3Ks-drug targets in inflammation and cancer.

Author information

1
Institute Biochemistry & Genetics, Department Biomedicine, University of Basel, Mattenstrasse 28, 4058, Basel, Switzerland, Matthias.Wymann@UniBas.CH.

Abstract

Phosphoinositide 3-kinases (PI3Ks) control cell growth, proliferation, cell survival, metabolic activity, vesicular trafficking, degranulation, and migration. Through these processes, PI3Ks modulate vital physiology. When over-activated in disease, PI3K promotes tumor growth, angiogenesis, metastasis or excessive immune cell activation in inflammation, allergy and autoimmunity. This chapter will introduce molecular activation and signaling of PI3Ks, and connections to target of rapamycin (TOR) and PI3K-related protein kinases (PIKKs). The focus will be on class I PI3Ks, and extend into current developments to exploit mechanistic knowledge for therapy.

PMID:
22403076
DOI:
10.1007/978-94-007-3012-0_5
[Indexed for MEDLINE]

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