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Stroke. 2012 Apr;43(4):939-45. doi: 10.1161/STROKEAHA.111.639435. Epub 2012 Mar 8.

Alcohol consumption and risk of stroke in women.

Author information

1
Division of Preventive Medicine, Brigham and Women’s Hospital, Boston, MA 02215, USA.

Abstract

BACKGROUND AND PURPOSE:

Light-to-moderate alcohol consumption has been consistently associated with lower risk of heart disease, but data for stroke are less certain. A lower risk of stroke with light-to-moderate alcohol intake has been suggested, but the dose response among women remains uncertain and the data in this subgroup have been sparse.

METHODS:

A total of 83 578 female participants of the Nurses' Health Study who were free of diagnosed cardiovascular disease and cancer at baseline were followed-up from 1980 to 2006. Data on self-reported alcohol consumption were assessed at baseline and updated approximately every 4 years, whereas stroke and potential confounder data were updated at baseline and biennially. Strokes were classified according to the National Survey of Stroke criteria.

RESULTS:

We observed 2171 incident strokes over 1 695 324 person-years. In multivariable adjusted analyses, compared to abstainers, the relative risks of stroke were 0.83 (95% CI, 0.75-0.92) for <5 g/d, 0.79 (95% CI, 0.70-0.90) for 5 to 14.9 g/d, 0.87 (0.72-1.05) for 15 to 29.9 g/d, and 1.06 (95% CI, 0.86-1.30) for 30 to 45 g/d. Results were similar for ischemic and hemorrhagic stroke.

CONCLUSIONS:

Light-to-moderate alcohol consumption was associated with a lower risk of total stroke. In this population of women with modest alcohol consumption, an elevated risk of total stroke related to alcohol was not observed.

PMID:
22403048
PMCID:
PMC3350838
DOI:
10.1161/STROKEAHA.111.639435
[Indexed for MEDLINE]
Free PMC Article

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