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Org Biomol Chem. 2012 Apr 21;10(15):2955-9. doi: 10.1039/c2ob07030h. Epub 2012 Mar 8.

Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines.

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1
Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany. viktor.iaroshenko@uni-rostock.de

Abstract

A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions.

PMID:
22402696
DOI:
10.1039/c2ob07030h
[Indexed for MEDLINE]
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