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Parasitol Res. 2012 Aug;111(2):571-5. doi: 10.1007/s00436-012-2869-y. Epub 2012 Mar 9.

Saliva and sera IgA and IgG in Egyptian Giardia-infected children.

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1
Department of Parasitology, Faculty of Medicine, Cairo University, Cairo, Egypt.

Abstract

Giardiasis is a gastrointestinal infection of wide distribution that is more prevalent in childhood. Easy and rapid diagnosis of giardiasis is essential for reduction of this infection. This cross-sectional study included 62 children in which collection of saliva, stool and serum samples was performed. An enzyme-linked immunosorbent assay (ELISA) technique was evaluated to detect IgA and IgG responses in both saliva and serum samples. Twenty-two children were positive for Giardia duodenalis infection by direct examination of faecal specimens, 20 non-infected and 20 infected with other parasites. Salivary and serum IgA and IgG responses against G. duodenalis infection were significantly higher in Giardia parasitized than non-Giardia parasitized children (pā€‰<ā€‰0.001). This concludes that specific salivary IgA may serve as a diagnostic tool and specific salivary IgG as a screening tool in monitoring the exposure of various populations to Giardia duodenalis. The advantage of salivary assays over serum immunoglobulin assay is being easy and non-invasive in sampling technique which is important especially for young children.

PMID:
22402609
DOI:
10.1007/s00436-012-2869-y
[Indexed for MEDLINE]

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