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Cancer Epidemiol. 2012 Aug;36(4):e201-6. doi: 10.1016/j.canep.2012.02.004. Epub 2012 Mar 7.

The association between UGT1A7 polymorphism and cancer risk: a meta-analysis.

Author information

1
Department of General Surgery, The Second Affiliated Hospital of Harbin Medical University, 246 Xuefu Road, Harbin 150086, China.

Abstract

BACKGROUND:

studies investigating the associations between UDP-glucuronosyltransferase 1A7 (UGT1A7) gene polymorphisms and various carcinomas risk reported conflicting results. To derive a more precise estimation of the association, we have conducted a meta-analysis.

METHODS:

data were collected from the following electronic databases: PubMed, Medline and Chinese Biomedical Literature Database, with the last report up to September 2011. Case-control studies containing available genotype frequencies of UGT1A7 were chose. The odds ratio (OR) and its 95% confidence interval (95%CI) were used to assess the strength of association.

RESULTS:

a total of 22 separate case-control studies including 3852 cases and 5604 controls based on the search criteria were involved in this meta-analysis. The combined results based on all studies showed that there was a statistically significant link between UGT1A7*3 allele and cancer risk (OR = 1.31, 95%CI = 1.14-1.50, P = 0.0001). In the stratified analysis by racial descent, significant increased risk was found in Asian population for UGT1A7*3 allele (OR = 1.41, 95%CI = 1.22-1.63, P < 0.00001). No significant associations were found between the UGT1A7 polymorphism and cancer susceptibility among Caucasians and African-Americans. In the subgroup analysis by cancer types, significant associations were found in UGT1A7*2 allele (OR = 1.23, 95%CI = 1.06-1.43, P = 0.006) and *3 allele (OR = 1.51, 95%CI = 1.11-2.06, P = 0.009) for hepatocellular carcinoma, *3 allele for lung cancer (OR = 1.36, 95%CI = 1.11-1.68, P = 0.004) and for bladder cancer (OR = 1.50, 95%CI = 1.09-2.07, P = 0.01).

CONCLUSIONS:

This meta-analysis suggests that the UGT1A7*3 allele is a risk factor for cancer among Asians, especially for hepatocellular carcinoma.

PMID:
22402308
DOI:
10.1016/j.canep.2012.02.004
[Indexed for MEDLINE]

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