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Am J Ophthalmol. 1990 Nov 15;110(5):513-7.

Cholesterol localization in ultrathin frozen sections in Schnyder's corneal crystalline dystrophy.

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Department of Ophthalmology, University of Maryland, Baltimore 21201.


We examined a 57-year-old woman who had bilateral corneal crystalline deposits associated with xanthelasma. The patient's son had bilateral stromal haze. Plasma cholesterol and apolipoprotein A-I and B levels were normal. Histopathologic examination disclosed lipid deposits, particularly in the superficial stroma and Bowman's layer. These deposits stained with oil red O and filipin, a fluorescent probe that specifically detects unesterified cholesterol. Cryoultramicrotomy disclosed more specific ultrastructural localization of unesterified cholesterol with an array of crystals resembling multiple plates in extracellular corneal tissue.

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