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Phys Rev Lett. 2012 Feb 3;108(5):058101. Epub 2012 Jan 30.

Optimal placement of origins for DNA replication.

Author information

1
Institute for Complex Systems and Mathematical Biology, SUPA, King's College, University of Aberdeen, Aberdeen 24 3UE, United Kingdom. jens.karschau@abdn.ac.uk

Abstract

DNA replication is an essential process in biology and its timing must be robust so that cells can divide properly. Random fluctuations in the formation of replication starting points, called origins, and the subsequent activation of proteins lead to variations in the replication time. We analyze these stochastic properties of DNA and derive the positions of origins corresponding to the minimum replication time. We show that under some conditions the minimization of replication time leads to the grouping of origins, and relate this to experimental data in a number of species showing origin grouping.

PMID:
22400964
PMCID:
PMC3476000
DOI:
10.1103/PhysRevLett.108.058101
[Indexed for MEDLINE]
Free PMC Article

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