Format

Send to

Choose Destination
BMC Complement Altern Med. 2012 Mar 9;12:14. doi: 10.1186/1472-6882-12-14.

Laxative effects of partially defatted flaxseed meal on normal and experimental constipated mice.

Author information

1
Department of Product Processing and Nutriology, Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, 2 Xudong Second Road, Wuhan 430062, People's Republic of China.

Abstract

BACKGROUND:

Constipation is a very common health problem in the world. Intake of sufficient amount of dietary fibers is a cornerstone in the prevention and treatment of constipation. As a traditional medicine, flaxseed has been used to treat constipation for centuries, but the controlled trials are rare. The purpose of the present study was to assess that whether partially defatted flaxseed meal (PDFM) has the potential role to facilitate fecal output in normal and experimental constipated mice.

METHODS:

After supplemented with 2.5%, 5% and 10% (w/w) PDFM (L-, M- and H-PDFM) for 14 days, the constipation models of mice were induced by atropine-diphenoxylate. The small intestinal transit rates, start time of defecation, amount of defecation and wet weight of feces were researched in normal and constipation model mice.

RESULTS:

M- and H-PDFM significantly increase small intestinal transit rates in constipation model mice. All dose of PDFM markedly shortened the start time of defecation and M- and H-PDFM significantly increase stool frequency and weight in both normal and constipation model mice.

CONCLUSIONS:

PDFM may be a useful laxative to facilitate fecal output in normal and constipation conditions.

PMID:
22400899
PMCID:
PMC3353840
DOI:
10.1186/1472-6882-12-14
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center