Format

Send to

Choose Destination
See comment in PubMed Commons below
Hypertens Res. 2012 May;35(5):477-84. doi: 10.1038/hr.2012.30. Epub 2012 Mar 8.

The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies?

Author information

1
Department of Functional Pathology, Shimane University School of Medicine, Izumo, Japan. nabika@med.shimane-u.ac.jp

Abstract

The stroke-prone spontaneously hypertensive rat (SHRSP) is a unique genetic model of severe hypertension and cerebral stroke. SHRSP, as well as the spontaneously hypertensive rat, the parental strain of SHRSP, has made a tremendous contribution to cardiovascular research. However, the genetic mechanisms underlying hypertension and stroke in these rats have not yet been clarified. Recent studies using whole-genome sequencing and comprehensive gene expression analyses combined with classical quantitative trait loci analyses provided several candidate genes, such as Ephx2, Gstm1 and Slc34a1, which still need further evidence to define their pathological roles. Currently, genome-wide association studies can directly identify candidate genes for hypertension in the human genome. Thus, genetic studies in SHRSP and other rat models must be focused on the pathogenetic roles of 'networks of interacting genes' in hypertension, instead of searching for individual candidate genes.

PMID:
22399095
DOI:
10.1038/hr.2012.30
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center