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Curr Opin Pharmacol. 2012 Jun;12(3):363-71. doi: 10.1016/j.coph.2012.02.008. Epub 2012 Mar 5.

Oestrogen's regulation of fat metabolism during exercise and gender specific effects.

Author information

1
Exercise Laboratory, School of Physiology, Faculty of Health Science, University of Witwatersrand, Medical School, Johannesburg, South Africa. oosthuyse@polka.co.za

Abstract

Early animal, menstrual phase and gender comparative studies inconsistently support an oestrogen-induced increase in fat oxidation during exercise. Recent advances from studies of cellular signalling and gene expression provide evidence for inter-tissue and intramuscular mechanisms that demonstrate oestrogen's promotion of skeletal muscle fat oxidative capacity. Oestrogen or oestrogen-analogues act mainly through oestrogen receptor-alpha in skeletal muscle to stimulate the genomic expression of certain other nuclear hormone receptors and downstream targets to promote long chain fatty acid (LCFA) uptake, mitochondrial shuttling and β oxidation. Oestrogen increases the availability of LCFA substrate by enhancing adipocyte lipolysis and expression of genes promoting intramyocellular lipid storage. Oestrogen acts by non-genomic means to increase the activation of AMPK that may reinforce some direct genomic actions.

PMID:
22398320
DOI:
10.1016/j.coph.2012.02.008
[Indexed for MEDLINE]

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