Send to

Choose Destination
Curr Opin Pharmacol. 2012 Jun;12(3):363-71. doi: 10.1016/j.coph.2012.02.008. Epub 2012 Mar 5.

Oestrogen's regulation of fat metabolism during exercise and gender specific effects.

Author information

Exercise Laboratory, School of Physiology, Faculty of Health Science, University of Witwatersrand, Medical School, Johannesburg, South Africa.


Early animal, menstrual phase and gender comparative studies inconsistently support an oestrogen-induced increase in fat oxidation during exercise. Recent advances from studies of cellular signalling and gene expression provide evidence for inter-tissue and intramuscular mechanisms that demonstrate oestrogen's promotion of skeletal muscle fat oxidative capacity. Oestrogen or oestrogen-analogues act mainly through oestrogen receptor-alpha in skeletal muscle to stimulate the genomic expression of certain other nuclear hormone receptors and downstream targets to promote long chain fatty acid (LCFA) uptake, mitochondrial shuttling and β oxidation. Oestrogen increases the availability of LCFA substrate by enhancing adipocyte lipolysis and expression of genes promoting intramyocellular lipid storage. Oestrogen acts by non-genomic means to increase the activation of AMPK that may reinforce some direct genomic actions.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center