Format

Send to

Choose Destination
J Virol. 2012 May;86(10):5931-6. doi: 10.1128/JVI.00451-12. Epub 2012 Mar 7.

TNPO3 is required for HIV-1 replication after nuclear import but prior to integration and binds the HIV-1 core.

Author information

1
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA.

Abstract

TNPO3 is a nuclear importer required for HIV-1 infection. Here, we show that depletion of TNPO3 leads to an HIV-1 block after nuclear import but prior to integration. To investigate the mechanistic requirement of TNPO3 in HIV-1 infection, we tested the binding of TNPO3 to the HIV-1 core and found that TNPO3 binds to the HIV-1 core. Overall, this work suggests that TNPO3 interacts with the incoming HIV-1 core in the cytoplasm to assist a process that is important for HIV-1 infection after nuclear import.

PMID:
22398280
PMCID:
PMC3347269
DOI:
10.1128/JVI.00451-12
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center