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Trends Cell Biol. 2012 May;22(5):257-65. doi: 10.1016/j.tcb.2012.02.003. Epub 2012 Mar 5.

Non-canonical Notch signaling: emerging role and mechanism.

Author information

1
Division of Cardiology, Department of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA.

Abstract

Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although the 'canonical' Notch pathway and its core members are well established - involving ligand-induced cleavage of Notch for transcriptional regulation - it has been unclear whether Notch can also function independently of ligand and transcription ('non-canonically') through a common mechanism. Recent studies suggest that Notch can non-canonically exert its biological functions by post-translationally targeting Wnt/β-catenin signaling, an important cellular and developmental regulator. The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology.

PMID:
22397947
PMCID:
PMC3348455
DOI:
10.1016/j.tcb.2012.02.003
[Indexed for MEDLINE]
Free PMC Article

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