Format

Send to

Choose Destination
See comment in PubMed Commons below
Nucleic Acids Res. 2012 Jul;40(12):5523-34. doi: 10.1093/nar/gks215. Epub 2012 Mar 6.

Related haloarchaeal pleomorphic viruses contain different genome types.

Author information

1
Department of Biosciences and Institute of Biotechnology, University of Helsinki, P.O. Box 56, FIN-00014 University of Helsinki, Finland.

Abstract

Archaeal viruses have been the subject of recent interest due to the diversity discovered in their virion architectures. Recently, a new group of haloarchaeal pleomorphic viruses has been discovered. It is distinctive in terms of the virion morphology and different genome types (ssDNA/dsDNA) harboured by rather closely related representatives. To date there are seven isolated viruses belonging to this group. Most of these share a cluster of five conserved genes, two of which encode major structural proteins. Putative proviruses and proviral remnants containing homologues of the conserved gene cluster were also identified suggesting a long-standing relationship of these viruses with their hosts. Comparative genomic analysis revealed three different ways of the genome organization, which possibly reflect different replication strategies employed by these viruses. The dsDNA genomes of two of these viruses were shown to contain single-strand interruptions. Further studies on one of the genomes suggested that the interruptions are located along the genome in a sequence-specific manner and exhibit polarity in distribution.

PMID:
22396526
PMCID:
PMC3384331
DOI:
10.1093/nar/gks215
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Silverchair Information Systems Icon for PubMed Central
    Loading ...
    Support Center