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J Neurosci. 2012 Feb 15;32(7):2252-62. doi: 10.1523/JNEUROSCI.5493-11.2012.

Tamalin is a critical mediator of electroconvulsive shock-induced adult neuroplasticity.

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1
Neural Development Section, Mouse Cancer Genetics Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702, USA.

Abstract

The molecular mechanisms underlying the effects of electroconvulsive shock (ECS) therapy, a fast-acting and very effective antidepressant therapy, are poorly understood. Changes related to neuroplasticity, including enhanced adult hippocampal neurogenesis and neuronal arborization, are believed to play an important role in mediating the effects of ECS. Here we show a dynamic upregulation of the scaffold protein tamalin, selectively in the hippocampus of animals subjected to ECS. Interestingly, this gene upregulation is functionally significant because tamalin deletion in mice abrogated ECS-induced neurogenesis in the adult mouse hippocampus. Furthermore, loss of tamalin blunts mossy fiber sprouting and dendritic arborization caused by ECS. These data suggest an essential role for tamalin in ECS-induced adult neuroplasticity and provide new insight into the pathways that are involved in mediating ECS effects.

PMID:
22396401
PMCID:
PMC3780770
DOI:
10.1523/JNEUROSCI.5493-11.2012
[Indexed for MEDLINE]
Free PMC Article
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