Format

Send to

Choose Destination
J Trop Pediatr. 2012 Oct;58(5):382-8. doi: 10.1093/tropej/fms005. Epub 2012 Mar 6.

Therapeutic hypothermia using gel packs for term neonates with hypoxic ischaemic encephalopathy in resource-limited settings: a randomized controlled trial.

Author information

1
Department of Paediatrics, Division of Neonatology, JIPMER, Puducherry, 605 006, India. skb_bmc@yahoo.co.in

Abstract

OBJECTIVE:

To evaluate the efficacy of therapeutic hypothermia (TH) using gel packs in reducing mortality and morbidity in term neonates with HIE and study the associated problems with TH.

METHODS:

Hypoxic ischaemic encephalopathy babies were randomized into TH and control group. Babies in TH group were cooled for first 72 h of birth using cloth covered cooling gel packs to maintain target rectal temperature of 33-34°C. Infants were followed up to 6 months and were assessed using Baroda Developmental Screening Test.

RESULTS:

There were no significant differences in baseline parameters. TH group showed significant reduction in the combined rate of death or developmental delay at 6 months of age by 21% (8.1% in the TH group vs. 29% in the control, RR 0.28, 95% CI: 0.11-0.70; p = 0.003).

CONCLUSIONS:

TH using gel packs reduces the risk of death or developmental delay at 6 months of age in infants with HIE.

PMID:
22396230
DOI:
10.1093/tropej/fms005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center