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Chemphyschem. 2012 Apr 23;13(6):1444-7. doi: 10.1002/cphc.201100980. Epub 2012 Mar 6.

Intracellular conformations of human telomeric quadruplexes studied by electron paramagnetic resonance spectroscopy.

Author information

1
Department of Chemistry, Konstanz Research School Chemical Biology (KoRS-CB) and Zukunftskolleg, University of Konstanz, Konstanz, Germany.

Abstract

In-cell DEER (in-cell double electron electron resonance) is applied to investigate quadruplex formation of the human telomeric repeat d[AGGG(TTAGGG)(3)]. The initially unfolded DNA sequence forms a mixture of different quadruplex topologies upon injection into living cells. In addition, time-dependent distance measurements are carried out to monitor quadruplex folding.

PMID:
22396158
DOI:
10.1002/cphc.201100980
[Indexed for MEDLINE]
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