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Curr Protoc Nucleic Acid Chem. 2012 Mar;Chapter 14:Unit 14.8.1-7. doi: 10.1002/0471142700.nc1408s48.

One-flask synthesis of cyclic diguanosine monophosphate (c-di-GMP).

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1
Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, USA.

Abstract

The bacterial signaling molecule, cyclic diguanosine monophosphate (c-di-GMP), plays a key role in controlling biofilm formation and pathogenic virulence, among many other functions. It has widespread consequences for human health, and current research is actively exploring its molecular mechanisms. The convenient one-flask, gram-scale synthesis of c-di-GMP described here will facilitate these efforts.

PMID:
22395965
PMCID:
PMC3319711
DOI:
10.1002/0471142700.nc1408s48
[Indexed for MEDLINE]
Free PMC Article
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