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Nat Rev Mol Cell Biol. 2012 Mar 7;13(4):225-238. doi: 10.1038/nrm3293.

Sirtuins as regulators of metabolism and healthspan.

Author information

1
Laboratory for Integrative and Systems Physiology, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.
2
Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, Biocenter Kuopio, University of Eastern Finland, Kuopio, Finland.
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Contributed equally

Abstract

Since the beginning of the century, the mammalian sirtuin protein family (comprising SIRT1-SIRT7) has received much attention for its regulatory role, mainly in metabolism and ageing. Sirtuins act in different cellular compartments: they deacetylate histones and several transcriptional regulators in the nucleus, but also specific proteins in other cellular compartments, such as in the cytoplasm and in mitochondria. As a consequence, sirtuins regulate fat and glucose metabolism in response to physiological changes in energy levels, thereby acting as crucial regulators of the network that controls energy homeostasis and as such determines healthspan.

PMID:
22395773
PMCID:
PMC4872805
DOI:
10.1038/nrm3293
[Indexed for MEDLINE]
Free PMC Article

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