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Reprod Fertil Dev. 2011;24(1):29-34. doi: 10.1071/RD11904.

The impact of obesity on oocytes: evidence for lipotoxicity mechanisms.

Author information

1
The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, SA 5005, Australia.

Abstract

Obesity can have detrimental effects on pregnancy rates in natural conceptions and also in women undergoing IVF or intracytoplasmic sperm injection (ICSI). This review summarises the most recent clinical literature investigating whether obesity impacts oocyte quality and early embryo growth. In other tissues, obesity leads to lipotoxicity responses including endoplasmic reticulum stress, mitochondrial dysfunction and apoptosis. Recent reports indicate that lipotoxicity is a mechanism by which obesity may impact oocyte quality.

PMID:
22394715
DOI:
10.1071/RD11904
[Indexed for MEDLINE]

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