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Antimicrob Agents Chemother. 2012 Jun;56(6):3441-3. doi: 10.1128/AAC.05682-11. Epub 2012 Mar 5.

Bactericidal activity of multiple combinations of tigecycline and colistin against NDM-1-producing Enterobacteriaceae.

Author information

1
Bristol Centre for Antimicrobial Research and Evaluation, Department of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, United Kingdom. msalbur@hotmail.com

Abstract

The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.

PMID:
22391543
PMCID:
PMC3370758
DOI:
10.1128/AAC.05682-11
[Indexed for MEDLINE]
Free PMC Article

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