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Genes Dev. 2012 Mar 1;26(5):439-44. doi: 10.1101/gad.181800.111.

EZH2 couples pancreatic regeneration to neoplastic progression.

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1
Department of Biochemistry, New York University School of Medicine, New York, NY 10016, USA.

Abstract

Although the polycomb group protein Enhancer of Zeste Homolog 2 (EZH2) is well recognized for its role as a key regulator of cell differentiation, its involvement in tissue regeneration is largely unknown. Here we show that EZH2 is up-regulated following cerulein-induced pancreatic injury and is required for tissue repair by promoting the regenerative proliferation of progenitor cells. Loss of EZH2 results in impaired pancreatic regeneration and accelerates KRas(G12D)-driven neoplasia. Our findings implicate EZH2 in constraining neoplastic progression through homeostatic mechanisms that control pancreatic regeneration and provide insights into the documented link between chronic pancreatic injury and an increased risk for pancreatic cancer.

PMID:
22391448
PMCID:
PMC3305982
DOI:
10.1101/gad.181800.111
[Indexed for MEDLINE]
Free PMC Article

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