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Placenta. 2012 Jun;33(6):518-21. doi: 10.1016/j.placenta.2012.02.014. Epub 2012 Mar 3.

Hydrogen sulfide producing enzymes in pregnancy and preeclampsia.

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Department of Pathology and Medical Biology, Division of Pathology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9713 GZ Groningen, The Netherlands.


Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H(2)S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H(2)S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H(2)S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H(2)S-production and may aid in the anti-angiogenic state.

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