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Vitam Horm. 2012;88:439-59. doi: 10.1016/B978-0-12-394622-5.00019-5.

"Patch"-ing up the neurons: revival or enervation?

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Structural Genomics Division, Saha Institute of Nuclear Physics, Kolkata, West Bengal, India.


Since its identification Patched1 (Ptch1) has gained importance for playing a cardinal role in developmental patterning through Hedgehog (Hh) pathway, acting as a transmembrane receptor. Involvement of this protein in diverse aspects of the neuronal system, from development to regeneration and protection, including uncontrolled proliferation in oncogenic perspectives, makes it an intriguing candidate for investigation in neurobiology. Stem cell population of adult nervous system is also found to be regulated by Ptch1. Though not elaborately studied, research in this field for the past one decade has suggested a new spectrum of Ptch1 function through an alternative route independent of Hh. In this chapter, the available knowledge about Ptch1 in neuronal system is critically reviewed and further functional insights about this protein are evaluated.

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