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Nutr Neurosci. 2012 Jul;15(4):171-5. doi: 10.1179/1476830512Y.0000000005. Epub 2012 Feb 16.

Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice.

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1
Universidade Federal de São Paulo, São Paulo, SP, Brazil.

Abstract

OBJECTIVE:

The objective of the present study was to assess whether the administration of polyunsaturated fatty acids (PUFAs) would lead to alterations in cocaine-conditioned place preference by correlating behavioral data and plasma levels of PUFAs.

METHODS:

Five groups of C57Bl/6J mice received a linseed oil supplement or a control solution for 19 days and were conditioned to cocaine.

RESULTS:

PUFAs did not exert a protective effect against cocaine-conditioned place-preference behavior, although there were significant differences in the levels of eicosapentaenoic acid (EPA) and linoleic acid among the groups tested. Higher doses of PUFAs might be necessary to induce a change in the plasma level of EPA in cocaine-conditioned mice.

DISCUSSION:

PUFAs had no effect on cocaine-conditioned place preference.

PMID:
22390908
DOI:
10.1179/1476830512Y.0000000005
[Indexed for MEDLINE]
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