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World J Surg Oncol. 2012 Mar 5;10:48. doi: 10.1186/1477-7819-10-48.

Pathological impairments induced by interstitial implantation of 125I seeds in spinal canal of banna mini-pigs.

Author information

1
Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan 650118, PR China. yangzuozhangsci@163.com

Abstract

BACKGROUND:

Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.

METHODS:

In present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.

RESULTS:

In this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.

CONCLUSIONS:

Without any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.

PMID:
22390740
PMCID:
PMC3312839
DOI:
10.1186/1477-7819-10-48
[Indexed for MEDLINE]
Free PMC Article

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