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J Cell Biochem. 2012 Jul;113(7):2201-7. doi: 10.1002/jcb.24116.

The emerging role of Arf/Arl small GTPases in cilia and ciliopathies.

Author information

1
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA. li.yujie@mayo.edu

Abstract

Once overlooked as an evolutionary vestige, the primary cilium has recently been the focus of intensive studies. Mounting data show that this organelle is a hub for various signaling pathways during vertebrate embryonic development and pattern formation. However, how cilia form and how cilia execute the sensory function still remain poorly understood. Cilia dysfunction is correlated with a wide spectrum of human diseases, now termed ciliopathies. Various small GTPases, including the members in Arf/Arl, Rab, and Ran subfamilies, have been implicated in cilia formation and/or function. Here we review and discuss the role of one particular group of small GTPase, Arf/Arl, in the context of cilia and ciliopathy.

PMID:
22389062
PMCID:
PMC4133128
DOI:
10.1002/jcb.24116
[Indexed for MEDLINE]
Free PMC Article

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