Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Struct Mol Biol. 2012 Mar 4;19(4):461-3. doi: 10.1038/nsmb.2250.

Structure of the human metapneumovirus fusion protein with neutralizing antibody identifies a pneumovirus antigenic site.

Author information

1
Department of Structural Biology, Stanford University School of Medicine, Stanford, California, USA.

Abstract

Human metapneumovirus and respiratory syncytial virus cause lower respiratory tract infections. The virus fusion (F) glycoprotein promotes membrane fusion by refolding from a metastable pre-fusion to a stable post-fusion conformation. F is also a major target of the neutralizing antibody response. Here we show that a potently neutralizing anti-human metapneumovirus antibody (DS7) binds a structurally invariant domain of F, revealing a new epitope that could be targeted in vaccine development.

PMID:
22388735
PMCID:
PMC3546531
DOI:
10.1038/nsmb.2250
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group Icon for PubMed Central
    Loading ...
    Support Center