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Biosystems. 2012 Jul;109(1):52-6. doi: 10.1016/j.biosystems.2012.02.001. Epub 2012 Feb 23.

Continuous computation in engineered gene circuits.

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1
School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, United Kingdom. a.moreno@mmu.ac.uk

Abstract

In this paper we consider the problem of representation and measurement in genetic circuits, and investigate how they can affect the reliability of engineered systems. We propose a design scheme, based on the notion of continuous computation, which addresses these issues. We illustrate the methodology by showing how a concept from computer architecture (namely, branch prediction) may be implemented in vivo, using a distributed approach. Simulation results confirm the in-principle feasibility of our method, and offer valuable insights into its future laboratory validation.

[Indexed for MEDLINE]

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